Article
Telomere Integrity, Epigenetic Aging, and Genetic Burden Shape Biological Aging Trajectories in Idiopathic Pulmonary Fibrosis
2025-10-15
Abstract excerpt
<title>Abstract</title> <p> Idiopathic pulmonary fibrosis (IPF) is a paradigmatic aging-related lung disorder. We studied 101 treatment-naïve patients at diagnosis (T0) and a subgroup (n = 31) after one year of antifibrotic therapy (T1) including leukocyte telomere length (LTL), DNA methylation age (DNAmAge by Horvath, Levine/PhenoAge, and a 5-CpGs panel), age acceleration (AgeAcc), and 17 IPF-associated SNPs su...
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Identifiers and source
- Literature Corpus work
- 4c455859-4a9d-5f3c-8914-cd7474710ddd
- DOI
- 10.21203/rs.3.rs-7686711/v1