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Article

Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication.

International journal of hematology - 1 Oct 2006

Takahashi Shinichiro, Harigae Hideo, Yokoyama Hisayuki, Ishikawa Izumi, Abe Shouri, Imaizumi Masue, Sasaki Takeshi, Kaku Mitsuo

Abstract excerpt

Flt3 internal tandem duplication (Flt3-ITD) is a prevalent mutation in acute myeloid leukemia (AML). Flt3-ITD constitutively activates various signaling pathways, including a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway. Arsenic trioxide (ATO) and MEK inhibition were recently reported to interact synergistically to induce apoptosis in AML cells. In this study,...

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Identifiers

PMID: 17050201
DOI: 10.1532/IJH97.06076

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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