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Article

Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1

2 Feb 2010

Abstract excerpt

Mutations of the inositol 5' phosphatase oculocerebrorenal syndrome of Lowe (OCRL) give rise to the congenital X-linked disorders oculocerebrorenal syndrome of Lowe and Dent disease, two conditions giving rise to abnormal kidney proximal tubule reabsorption, and additional nervous system and ocular defects in the case of Lowe syndrome. Here, we identify two closely related endocytic proteins, Ses1 and Ses2, which...

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Identifiers

PMID: 20133602
DOI: 10.1073/pnas.0914658107

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two closely related endocytic proteins that share a common OCRL-binding motif with APPL1PMID 20133602Read ↗

All known patient mutations in the ASH-RhoGAP domains of OCRL affect targeting and APPL1 binding.Semantic proximity Read ↗

A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway.Semantic proximity Read ↗

The PH domain proteins IPIP27A and B link OCRL1 to receptor recycling in the endocytic pathway.Semantic proximity Read ↗

The 5-phosphatase OCRL in Lowe syndrome and Dent disease 2.Semantic proximity Read ↗

The oculocerebrorenal syndrome of Lowe: an update.Semantic proximity Read ↗

The cellular and physiological functions of the Lowe syndrome protein OCRL1.Semantic proximity Read ↗

The Lowe Syndrome Protein OCRL1 Is Required for Endocytosis in the Zebrafish Pronephric TubuleSemantic proximity Read ↗

A structural basis for Lowe syndrome caused by mutations in the Rab-binding domain of OCRL1.Semantic proximity Read ↗

Inositol 5-phosphatases: insights from the Lowe syndrome protein OCRLSemantic proximity Read ↗

Structure and function of the Lowe syndrome protein OCRL1.Semantic proximity Read ↗

Deficiency in the endocytic adaptor protein PHETA1/2 impairs renal and craniofacial developmentSemantic proximity Read ↗

Deficiency in the endocytic adaptor proteins PHETA1/2 impairs renal and craniofacial development.Semantic proximity Read ↗

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