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Oncogenic PTPN11/SHP2 drives immune escape in juvenile myelomonocytic leukemia (JMML) through activation of ectonucleotidase/adenosine signaling

2025-10-02

Abstract excerpt

<h4>ABSTRACT</h4> Juvenile myelomonocytic leukemia (JMML) is a myelodysplastic/myeloproliferative neoplasm of early childhood driven by RAS pathway mutations. Allogeneic hematopoietic stem cell transplantation (HSCT) is the therapy of choice for most patients. However, relapse rate is high, in patients with adverse features, frequently noted in PTPN11 -mutated JMML, or in patients without evidence of graft-versu...

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Literature Corpus work
70fca49b-0d42-5fa8-a276-85bf0f0271d7
DOI
10.1101/2025.10.01.679664
Open publication

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Oncogenic PTPN11/SHP2 drives immune escape in juvenile myelomonocytic leukemia (JMML) through activation of ectonucleotidase/adenosine signalingDOI 10.1101/2025.10.01.679664
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