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Article

Targeted therapy in juvenile myelomonocytic leukemia: Where are we now?

Pediatric blood & cancer - 1 Nov 2022

De Vos Nele, Hofmans Mattias, Lammens Tim, De Wilde Bram, Van Roy Nadine, De Moerloose Barbara

Abstract excerpt

Juvenile myelomonocytic leukemia (JMML) is a rare and aggressive clonal neoplasm of early childhood, classified as an overlap myeloproliferative/myelodysplastic neoplasm by the World Health Organization. In 90% of the patients with JMML, typical initiating mutations in the canonical Ras pathway genes NF1, PTPN11, NRAS, KRAS, and CBL can be identified. Hematopoietic stem cell transplantation (HSCT) currently is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36094370
DOI: 10.1002/pbc.29930

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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