Article

Bacterial lipoate protein ligases rescue lipoylation and respiration deficiency in mammals

2024-11-25

Abstract excerpt

<h4>Summary</h4> Human lipoylation pathway deficiencies caused by LIPT2/LIAS/LIPT1 gene mutations lead to inherited metabolic disorders characterized by severe defects of mitochondrial energy and amino acids metabolism. Patients with such mutations suffer from hyperlactic acidemia, encephalopathy, hypotonia and early death. So far there is no effective treatment. Here we introduced the bacteria salvage lipoylatio...

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Literature Corpus work: 70e87c31-2133-5d34-ae9a-0109a9aa61b4
DOI: 10.1101/2024.11.22.624956

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