Article

Inhibition of the phosphoinositide 3-kinase-AKT-cyclic GMP-c-Jun N-terminal kinase signaling pathway attenuates the development of morphine tolerance in a mouse model of neuropathic pain

2020-10-14

Abstract excerpt

<h4>Background</h4> Opioid management of chronic pain can cause opioid-induced analgesic tolerance and hyperalgesia, complicating clinical pain-management treatments. Research presented here sought to determine if opioid induced tolerance is linked to activity changes within the PI3Kγ-AKT-cGMP-JNK intracellular signaling pathway in spinal cord or peripheral nervous systems. <h4>Methods</h4> Morphine or saline in...

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Literature Corpus work: 708a5561-93d1-5498-85d2-c9f627985bae
DOI: 10.1101/2020.10.14.340067

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