Annexin A2 plays a key role in protecting against acute kidney injury through β-catenin/TFEB pathway

Abstract excerpt

<title>Abstract</title> <p>Aim Acute kidney injury (AKI) is becoming a heavy health burden worldwide. There are no effective therapeutic strategies nowadays. Recent studies showed that autophagy and lysosome stabilization could inhibit tubular cell apoptosis, and protect against AKI. Annexin A2 (ANXA2), a calcium-regulated phospholipid-binding protein, was found to be highly involved in autophagy. However, its r...

Topics

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• Acute Kidney Injury Research
• Biomarkers in Disease Mechanisms
• Blood Coagulation and Thrombosis Mechanisms
• Chronic Kidney Disease and Diabetes
• Computational Drug Discovery Methods
• Dialysis and Renal Disease Management
• Protease and Inhibitor Mechanisms
• S100 Proteins and Annexins

Identifiers and source

Literature Corpus work

58fd8a7e-315f-5c22-944b-d40c20c9c806

DOI

10.21203/rs.3.rs-1358680/v1