Article

Effect of Delta and Omicron mutations on the RBD-SD1 domain of the Spike protein in SARS-CoV-2 and the Omicron mutations on RBD-ACE2 interface complex

2022-07-28

Abstract excerpt

<h4>ABSTRACT</h4> The receptor-binding domain (RBD) is the essential part in the Spike-protein (S-protein) of SARS-CoV-2 virus that directly binds to the human ACE2 receptor, making it a key target for many vaccines and therapies. Therefore, any mutations at this domain could affect the efficacy of these treatments as well as the viral-cell entry mechanism. We introduce ab initio DFT-based computational study th...

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Literature Corpus work: 7061dabb-30ac-5c3f-a75a-1522f1dffe38
DOI: 10.1101/2022.07.28.501901

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