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Article

Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface Complex.

International journal of molecular sciences - 3 Sept 2022

Ching Wai-Yim, Adhikari Puja, Jawad Bahaa, Podgornik Rudolf

Abstract excerpt

The receptor-binding domain (RBD) is the essential part in the Spike-protein (S-protein) of SARS-CoV-2 virus that directly binds to the human ACE2 receptor, making it a key target for many vaccines and therapies. Therefore, any mutations at this domain could affect the efficacy of these treatments as well as the viral-cell entry mechanism. We introduce ab initio DFT-based computational study that mainly focuses...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 36077490
DOI: 10.3390/ijms231710091
PMCID: PMC9456519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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Effect of Delta and Omicron Mutations on the RBD-SD1 Domain of the Spike Protein in SARS-CoV-2 and the Omicron Mutations on RBD-ACE2 Interface Complex.PMID 36077490Read ↗

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