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Article

Different aspects in explaining how mutations could affect the binding mechanism of receptor binding domain of SARS-CoV-2 spike protein in interaction with ACE2.

PloS one - 1 Jan 2023

Jafary Farzaneh, Joozdani Farzane Abasi, Shahzamani Kiana, Jafari Sepideh, Mirhendi Hossein, Ganjalikhany Mohamad Reza

Abstract excerpt

During replication, some mutations occur in SARS-CoV-2, the causal agent of COVID-19, leading to the emergence of different variants of the virus. The mutations that accrue in different variants of the virus, influence the virus' ability to bind to human cell receptors and ability to evade the human immune system, the rate of viral transmission, and effectiveness of vaccines. Some of these mutations occur in the...

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Identifiers

PMID: 37682927
DOI: 10.1371/journal.pone.0291210
PMCID: PMC10490914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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