Article

Extensive adaptive immune response of AAVs and Cas proteins in non-human primates

2019-03-25

Abstract excerpt

The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy. However, pre-existing adaptive immune responses against CRISPR nuclease (PAIR-C) and AAVs has been found in human serum, indicating that immune response is a problem...

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Literature Corpus work: 700bb592-8542-58da-9193-6c22d631d5f3
DOI: 10.1101/588913

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