Article

Reversal of cardiac and skeletal manifestations of Duchenne muscular dystrophy by cardiosphere-derived cells and their exosomes in <i>mdx</i> dystrophic mice and in human Duchenne cardiomyocytes

2017-04-20

Abstract excerpt

Genetic deficiency of dystrophin leads to disability and premature death in Duchenne muscular dystrophy, affecting the heart as well as skeletal muscle. Here we report that cardiosphere-derived cells (CDCs), which are being tested clinically for the treatment of Duchenne cardiomyopathy, improve cardiac and skeletal myopathy in the mdx mouse model of DMD and in human Duchenne cardiomyocytes. Injection of CDCs into...

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Literature Corpus work: 6fdc0bff-048a-5749-a912-57f0ffce7d1e
DOI: 10.1101/128900

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