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Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

1 May 2014

Abstract excerpt

The CADUCEUS trial of cardiosphere-derived cells (CDCs) has shown that it may be possible to regenerate injured heart muscle previously thought to be permanently scarred. The mechanisms of benefit are known to be indirect, but the mediators have yet to be identified. Here we pinpoint exosomes secreted by human CDCs as critical agents of regeneration and cardioprotection. CDC exosomes inhibit apoptosis and promote...

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PMID: 24936449
DOI: 10.1016/j.stemcr.2014.04.006

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