Article

Modelling and rescue of RP2 Retinitis Pigmentosa using iPSC Derived Retinal Organoids

2020-01-29

Abstract excerpt

<h4>Summary</h4> RP2 mutations cause a severe form of X-linked retinitis pigmentosa (XLRP). The mechanism of RP2 associated retinal degeneration in humans is unclear, and animal models of RP2 XLRP do not recapitulate this severe phenotype. Here, we developed gene edited isogenic RP2 knock-out (RP2 KO) induced pluripotent stem cells (iPSC) and RP2 patient derived iPSC to produce 3D retinal organoids as a human ret...

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Literature Corpus work: 26dd298d-2997-5c89-a1c4-5e4c8f0c7f97
DOI: 10.1101/2020.01.28.923227

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