Article

Uncovering the potential basis of the structural and functional glitches of VRQPrP

2022-03-30

Abstract excerpt

Altered physiologic function of prion is one of the proposed mechanisms of neurodegeneration through perturbed activities of PrPC.Experimental studies reported the link between sequence variation in the functional domains of prion protein and scrapie disease development .This study highlights how variants could potentially affect the prion protein dynamics i.e. conformational flexibility, ligand binding affinity,...

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Literature Corpus work: 6f101312-84d4-5dc1-bdbb-12164e805380
DOI: 10.22541/au.164864804.48462656/v1

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