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Article

The landscape of the prion protein's structural response to mutation revealed by principal component analysis of multiple NMR ensembles.

PLoS computational biology - 1 Jan 2012

Gendoo Deena M A, Harrison Paul M

Abstract excerpt

Prion Proteins (PrP) are among a small number of proteins for which large numbers of NMR ensembles have been resolved for sequence mutants and diverse species. Here, we perform a comprehensive principle components analysis (PCA) on the tertiary structures of PrP globular proteins to discern PrP subdomains that exhibit conformational change in response to point mutations and clade-specific evolutionary sequence...

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Identifiers

PMID: 22912570
DOI: 10.1371/journal.pcbi.1002646
PMCID: PMC3415401

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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