Article

Transitional lncRNA Signatures Reveal Distinct Stages of Cancer Progression and Metastasis

2025-06-16

Abstract excerpt

Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer, influencing gene expression, chromatin remodeling, and signaling. Evidence from The Cancer Genome Atlas (TCGA) and other datasets supports their role in tumor progression. Although the human genome harbors thousands lncRNA genes, only a small subset has been validated in cancer. In this study, we used the LncBook catalog (∼95,000 lncRNAs) to...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6edb62bf-20f7-5dac-8f57-ad23d8e9a93a
DOI: 10.1101/2025.06.10.658949

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transitional lncRNA Signatures Reveal Distinct Stages of Cancer Progression and MetastasisDOI 10.1101/2025.06.10.658949Read

Transitional lncRNA Signatures Reveal Distinct Stages of Cancer Progression and MetastasisSemantic proximity Read

Integrative prioritization of clinically and biologically relevant long noncoding RNAs across gastrointestinal cancersSemantic proximity Read

Lnc2Cancer 3.0: an updated resource for experimentally supported lncRNA/circRNA cancer associations and web tools based on RNA-seq and scRNA-seq data.Semantic proximity Read

Pan-cancer Analyses reveal functional similarities of three lncRNAs across multiple tumorsSemantic proximity Read

Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types.Semantic proximity Read

Long noncoding RNAs: lincs between human health and disease.Semantic proximity Read

Emerging role of long non-coding RNA (lncRNA) in human malignancies: A unique opportunity for precision medicineSemantic proximity Read

LncCE: Landscape of Cellular-Elevated LncRNAs in Single Cells Across Normal and Cancer TissuesSemantic proximity Read

LncTarD 2.0: an updated comprehensive database for experimentally-supported functional lncRNA–target regulations in human diseasesSemantic proximity Read

The landscape of long noncoding RNA-involved and tumor-specific fusions across various cancersSemantic proximity Read

Pan-cancer systematic identification of lncRNAs associated with cancer prognosisSemantic proximity Read

Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology.Semantic proximity Read