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Is HLA type a possible cancer risk modifier in Lynch syndrome?

10 Oct 2022

Abstract excerpt

Lynch syndrome (LS) is the most common inherited cancer syndrome. It is inherited via a monoallelic germline variant in one of the DNA mismatch repair (MMR) genes. LS carriers have a broad 30% to 80% risk of developing various malignancies, and more precise, individual risk estimations would be of high clinical value, allowing tailored cancer prevention and surveillance. Due to MMR deficiency, LS cancers are...

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PMID: 36214792
DOI: 10.1002/ijc.34312

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