Article
Mutation of the CH1 Domain in the Histone Acetyltransferase CREBBP Results in Autism-Relevant Behaviors in Mice.
PloS one - 1 Jan 2016
Zheng Fei, Kasper Lawryn H, Bedford David C, Lerach Stephanie, Teubner Brett J W, Brindle Paul K
Abstract excerpt
Autism spectrum disorders (ASDs) are a group of neurodevelopmental afflictions characterized by repetitive behaviors, deficits in social interaction, and impaired communication skills. For most ASD patients, the underlying causes are unknown. Genetic mutations have been identified in about 25 percent of ASD cases, including mutations in epigenetic regulators, suggesting that dysregulated chromatin or DNA function...
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