Back to search

Article

A combined Globo H-OCT4-T7 immunotherapy restrains colorectal tumor growth

2021-01-19

Abstract excerpt

<h4>Background: </h4> Malignant tumors express multiple common markers that might constitute targets for tumor immunotherapy. <h4>Methods:</h4> Here we performed antigen epitope screening and molecular docking to design a new combination vaccine based on covalently linking Globo H and Oct 4 with a TLR7 agonist. We mainly use flow cytometry to analyze the changes in lymphocyte differentiation after the vaccine is a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6e7a1663-6469-55d3-b88e-32765413f177
DOI
10.21203/rs.3.rs-147864/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A combined Globo H-OCT4-T7 immunotherapy restrains colorectal tumor growthDOI 10.21203/rs.3.rs-147864/v1
Strategies for developing and optimizing cancer vaccinesSemantic proximity
Lymph node-targeted Nanovaccine Reshapes the Tumor Microenvironment to Suppress PDAC Progression and MetastasisSemantic proximity
Efficacy of Bivalent CEACAM6/4-1BBL Genetic Vaccine Combined with Anti-PD1 Antibody in HCT116 Xenograft MiceSemantic proximity
AI/ML-Assisted Computational Design and Immunoinformatics Evaluation of a Multi-Epitope Vaccine Targeting Podoplanin in <i>Glioblastoma Multiforme</i>Semantic proximity
Immunotherapy for ovarian cancer is improved by tumor-targeted delivery of a neoantigen surrogateSemantic proximity
Fucosyltransferase 4-derived Peptide Bioconjugates on Carbon Nanotubes Enhance Antitumor Immunity in an Ovarian Cancer Mouse ModelSemantic proximity
Nanobody-based therapeutics against colorectal cancer: Precision therapies based on the personal mutanome profile and tumor neoantigens.Semantic proximity
CAR-T-drug conjugate against solid tumorSemantic proximity
The future of cancer vaccines against colorectal cancerSemantic proximity
A novel CAR T cell blend targeting PDPN and GD2 to overcome glioblastoma heterogeneitySemantic proximity
CDH17 as a Cell Surface Immunotherapy Target in Colorectal Cancer: An In Silico AnalysisSemantic proximity
A Peptide-Based, LNP-Free mRNA Vaccine Targeting Carcinoembryonic Antigen (CEA) for Potent Colorectal Cancer Immunotherapy: Development, Structural Dynamics, and Preclinical EfficacySemantic proximity
Select a neighboring publication to make it the new centre.