Article

Two distinct DNA sequences recognized by transcription factors represent enthalpy and entropy optima

2017-10-19

Abstract excerpt

<h4>SUMMARY</h4> Most transcription factors (TFs) can bind to a population of sequences closely related to a single optimal site. However, some TFs can bind to two distinct sequences that represent two local optima in the Gibbs free energy of binding (ΔG). To determine the molecular mechanism behind this effect, we solved the structures of human HOXB13 and CDX2 bound to their two optimal DNA sequences, CAATAAA an...

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Literature Corpus work: 6e71024d-66be-53a9-aa51-d0673c76f761
DOI: 10.1101/205906

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