Article

Derivatives of the antimalarial drug mefloquine are broad spectrum antifungal molecules with activity against drug-resistant clinical isolates

2019-11-22

Abstract excerpt

<h4>ABSTRACT</h4> The antifungal pharmacopeia is critically small, particularly in light of the recent emergence of multi-drug-resistant pathogens such as Candida auris . Herein, we report that derivatives of the anti-malarial drug mefloquine have broad spectrum antifungal activity against pathogenic yeasts and molds. In addition, the mefloquine derivatives have activity against clinical isolates that are resist...

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Literature Corpus work: 6e667066-7bd6-5f52-9ce5-8fe17622ff6a
DOI: 10.1101/851816

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