Article

RBPscan: A Quantitative, In Vivo Tool for Profiling RNA-Binding Protein Interactions

2025-01-04

Abstract excerpt

<h4>SUMMARY</h4> RNA-binding proteins (RBPs) are essential regulators of gene expression at post-transcriptional level, yet obtaining quantitative insights into RBP-RNA interactions in vivo remains a challenge. Here we developed RBPscan, a method that integrates RNA editing with massively parallel reporter assays (MPRAs) to profile RBP binding in vivo . RBPscan fuses the catalytic domain of ADAR to the RBP of i...

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Literature Corpus work: 6dfaddd1-9219-56f1-a341-ab497433f4a9
DOI: 10.1101/2025.01.03.631239

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