Back to search

Article

Discovering potential inhibitors against dengue virus NS5 RNA dependent RNA polymerase from local vegetables: a comparative computational study

2025-05-21

Abstract excerpt

Dengue virus (DENV) remains a global health challenge, necessitating the identification of novel inhibitors against its NS5 RNA-dependent RNA polymerase (RdRp), a critical enzyme for viral replication. This study evaluates the inhibitory potential of 270 phytochemicals from five local vegetables and computational approaches, with favipiravir as the control. Molecular docking revealed binding energies of -8.8, -8.7...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
6ddd114b-a842-5a20-8e01-fa89dbe02a56
DOI
10.1007/s44371-025-00198-9
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Discovering potential inhibitors against dengue virus NS5 RNA dependent RNA polymerase from local vegetables: a comparative computational studyDOI 10.1007/s44371-025-00198-9
Exploring Echinacea angustifolia for anti-viral compounds against Zika virus RNA-dependent RNA polymerase: a computational studySemantic proximity
A Review on the Progress and Prospects of Dengue Drug Discovery Targeting NS5 RNA- Dependent RNA PolymeraseSemantic proximity
Black seeds (Nigella sativa) for the management of Dengue viral disease: POM analyses for the identification of new antiviral pharmacophore sitesSemantic proximity
Antiviral Activity of an Indole-Type Compound Derived from Natural Products, Identified by Virtual Screening by Interaction on Dengue Virus NS5 ProteinSemantic proximity
Recent insights on anti-dengue virus (DENV) medicinal plants: review on in vitro , in vivo and in silico discoveriesSemantic proximity
Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymeraseSemantic proximity
Computational Study of SARS-CoV-2 RNA Dependent RNA Polymerase Allosteric Site InhibitionSemantic proximity
Repurposing FDA-approved drugs and natural compounds to inhibit the RNA-dependent RNA polymerase domain of dengue virus 2 or dengue virus 3Semantic proximity
Possible SARS-coronavirus 2 Inhibitor Revealed By Simulated Molecular Docking to Viral Main Protease and Host toll-like ReceptorSemantic proximity
Discovery of Bispecific Lead Compounds From Azadirachta Indica Against ZIKA NS2B-NS3 Protease and RNA Dependent RNA Polymerase Using Molecular SimulationsSemantic proximity
Network pharmacology, molecular docking, and dynamics analyses to predict the antiviral activityof ginger constituents against coronavirus infectionSemantic proximity
Mechanistic insights into the Japanese encephalitis virus RNA dependent RNA polymerase protein inhibition by bioflavonoids from Azadirachta indicaSemantic proximity
Select a neighboring publication to make it the new centre.