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ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

23 Mar 2023

Abstract excerpt

Autophagy is a cellular innate-immune defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). How canonical and non-canonical autophagy function to control Mtb infection in phagosomes and the cytosol remains unresolved. Macrophages are the main host cell in humans for Mtb. Here we studied the contributions of canonical and non-canonical autophagy in the genetically...

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PMID: 36959508
DOI: 10.1038/s41564-023-01335-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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