Article

Complex regulation of gamma-hemolysin expression impacts <i>S. aureus</i> virulence

2022-10-20

Abstract excerpt

Staphylococcus aureus gamma-hemolysin CB (HlgCB) is a core-genome encoded pore-forming toxin that targets the C5a receptor, similarly as the phage-encoded Panton-Valentine Leucocidin. Absolute quantification by mass spectrometry of HlgCB in 39 community-acquired pneumonia (CAP) isolates showed considerable variations in HlgC and HlgB yields between isolates. Interestingly, when testing the hypothesis that HlgCB mi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cd73f13-d42a-53b5-b905-39477b82c15a
DOI: 10.1101/2022.10.19.512982

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Complex regulation of gamma-hemolysin expression impacts <i>S. aureus</i> virulenceDOI 10.1101/2022.10.19.512982Read

<i>Staphylococcus aureus</i> virulence factor expression matters: input from targeted proteomics shows Panton-Valentine leucocidin impact on mortalitySemantic proximity Read

<i>PgaR</i> is a positive regulator of the <i>pgaABCD</i> biosynthetic operon in <i>Klebsiella pneumoniae</i>Semantic proximity Read

Global Changes in Staphylococcus aureus Gene Expression in Human BloodSemantic proximity Read

Regulatory effects on virulence and phage susceptibility revealed by <i>sdiA</i> mutation in <i>Klebsiella pneumoniae</i>Semantic proximity Read

Discovery of genes encoding a Streptolysin S-like toxin biosynthetic cluster in a select highly pathogenic methicillin resistant <i>Staphylococcus aureus</i> JKD6159 strainSemantic proximity Read

Insights into <i>Streptococcus Pyogenes</i> Pathogenesis from Transcriptome StudiesSemantic proximity Read

Extracellular proteases are key mediators of <scp> <i>S</i> </scp> <i>taphylococcus aureus</i> virulence via the global modulation of virulence‐determinant stabilitySemantic proximity Read

A direct link between carbohydrate utilization and virulence in the major human pathogen group A <i>Streptococcus</i>Semantic proximity Read

The Staphylococcus aureus CamS lipoprotein is a repressor of toxin production that shapes host-pathogen interactionSemantic proximity Read

Virulence Gene Expression in Human Community‐Acquired<i>Staphylococcus aureus</i>InfectionSemantic proximity Read

Comparative mortality of dominant <i>Staphylococcus aureus</i> lineages in human bacteremia and animal infection modelsSemantic proximity Read

Characterization of <i>Streptococcus pneumoniae</i> phage-like element SpnCI reveals an enhanced virulent phenotype in the acute invertebrate infection model <i>Galleria mellonella</i>Semantic proximity Read