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A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challenge

2022-12-19

Abstract excerpt

Monkeypox virus (MPXV) caused a global outbreak in 2022, fueled by behaviorally-altered and enhanced human-to-human transmission. While smallpox vaccines were rapidly deployed to curb spread and disease among those at highest risk, breakthrough disease was noted after complete immunization. Given the imminent threat of additional zoonotic events as well as the virus’ evolving ability to drive human-to-human transm...

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Literature Corpus work
6ccb4971-d8be-527e-bb70-8c6072c2a18a
DOI
10.1101/2022.12.17.520886
Open publication

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A monkeypox mRNA-lipid nanoparticle vaccine targeting virus binding, entry, and transmission drives protection against lethal orthopoxviral challengeDOI 10.1101/2022.12.17.520886
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