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Article

Intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers 2 survival-relevant subgroups of IDH1 wild-type glioblastoma.

Neuro-oncology - 9 Oct 2018

Stadlbauer Andreas, Zimmermann Max, Doerfler Arnd, Oberndorfer Stefan, Buchfelder Michael, Coras Roland, Kitzwögerer Melitta, Roessler Karl

Abstract excerpt

Background: The intratumoral heterogeneity of oxygen metabolism in combination with variable patterns of neovascularization (NV) as well as reprogramming of energy metabolism affects the landscape of tumor microenvironments (TMEs) in glioblastoma. Knowledge of the hypoxic and perivascular niches within the TME is essential for understanding treatment failure. Methods: Fifty-two patients with untreated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29718366
DOI: 10.1093/neuonc/noy066
PMCID: PMC6176796

Genes

IDH1

Provenance

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