Article

CD4+ T Cell Help Shapes Protective Humoral Immunity in Primary Dengue 2 Virus Infection: Implications for Rational Vaccine Design

2025-08-13

Abstract excerpt

<h4>Background: </h4> Understanding the immune mechanisms that differentiate protective from pathogenic responses during dengue virus (DENV) infection is critical for effective vaccine development. <h4>Objective:</h4> To investigate how CD4+ T cell depletion alters viral control and the humoral immune response during primary DENV2 infection in a non-human primate (NHP) model. <h4>Methods:</h4> Rhesus macaques were...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cb96e7f-a02a-5ba8-b739-50f325370963
DOI: 10.20944/preprints202508.0764.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

CD4+ T Cell Help Shapes Protective Humoral Immunity in Primary Dengue 2 Virus Infection: Implications for Rational Vaccine DesignDOI 10.20944/preprints202508.0764.v1Read

Dengue virus-specific memory B cell subsets differ as a function of infection historySemantic proximity Read

Dengue Virus Antibodies Enhance Zika Virus InfectionSemantic proximity Read

Immune outcomes of Zika virus infection in nonhuman primates.Semantic proximity Read

Dengue Vaccines: The Promise and Pitfalls of Antibody-Mediated Protection.Semantic proximity Read

Humoral Immune Responses Against Zika Virus Infection and the Importance of Preexisting Flavivirus ImmunitySemantic proximity Read

Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cellsSemantic proximity Read

BAFF-R and CD21 dysregulation inhibits memory B cell persistence in patients with common variable immunodeficiencySemantic proximity Read

Primary infection with dengue or Zika virus does not affect the severity of heterologous secondary infection in macaquesSemantic proximity Read

Long-term protection of rhesus macaques from Zika virus reinfectionSemantic proximity Read

Evolution of inflammation and immunity in a dengue virus 1 human infection modelSemantic proximity Read

Evolution of a Functionally Intact but Antigenically Distinct DENV Fusion LoopSemantic proximity Read

Prior flavivirus immunity skews the yellow fever vaccine response to expand cross-reactive antibodies with increased risk of antibody dependent enhancement of Zika and dengue virus infectionSemantic proximity Read