Article

The stretcher spontaneous neurodegenerative mutation models Charcot-Marie-Tooth disease type 4D

2013-02-13

Abstract excerpt

Mice affected by a spontaneous mutation which arose within our colony exhibited a neuromuscular phenotype involving tremor and characteristic stretching of the rear limbs. The mutant, named stretcher , was used to breed a backcross cohort for genetic mapping studies. The gene responsible for the mutant phenotype was mapped to a small region on mouse chromosome 15, with a LOD score above 20. Candidate genes within...

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Literature Corpus work: 6c5ef096-28bc-59b8-b620-8851588ee07d
DOI: 10.12688/f1000research.2-46.v1

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