Article
Genetic and physical delineation of the region overlapping the progressive motor neuropathy (pmn) locus on mouse chromosome 13.
Genomics - 1 Jul 2001
Martin N, Jaubert J, Glaser P, Szatanik M, Guénet J L
Abstract excerpt
The mouse autosomal recessive mutation progressive motor neuropathy (pmn) results in early onset motor neuron disease with rapidly progressing hindlimb paralysis, severe muscular wasting, and death at 4--6 weeks of age. pmn is thus considered a good animal model for motor neuron diseases and the characterization of the causative gene should help in understanding the biological causes of human spinal muscular...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Chromosomes, Artificial, Yeast
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 7
- Contig Mapping
- DNA, Complementary
- Gene Library
- Genes, Recessive
- Genetic Markers
- Haplotypes
- Hereditary Sensory and Motor Neuropathy