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Article

Systems Pharmacology of VEGF165b in Peripheral Artery Disease

28 Nov 2017

Abstract excerpt

We built a whole‐body computational model to study the role of the poorly understood vascular endothelial growth factor (VEGF)165b splice isoform in peripheral artery disease (PAD). This model was built and validated using published and new experimental data from cells, mice, and humans, and explicitly accounts for known properties of VEGF165b: lack of extracellular matrix (ECM)‐binding and weak phosphorylation...

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PMID: 29193887
DOI: 10.1002/psp4.12261

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