Article

Pluripotency and Transcriptional Pausing Disrupt Circadian Rhythms to Facilitate the Enrichment of Cancer Stem Cells

2026-07-13

Abstract excerpt

<h4>ABSTRACT/SUMMARY</h4> Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype, enriched for cancer stem cells (CSCs), which are the cause of tumor recurrence. CSCs are responsible for tumor initiation and propagation; however, the molecular mechanisms underlying their formation remain largely unclear. We show that carboplatin treated TNBC cells lose their circadian rhythms and promot...

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Literature Corpus work: 6c3812d5-a0b8-575d-85a1-e2d4b08bff08
DOI: 10.64898/2026.07.10.737844

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