Article
Induction of Neoantigen-Specific Cytotoxic T Cells and Construction of T-cell Receptor-Engineered T Cells for Ovarian Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2018
Matsuda Tatsuo, Leisegang Matthias, Park Jae-Hyun, Ren Lili, Kato Taigo, Ikeda Yuji, Harada Makiko, Kiyotani Kazuma, Lengyel Ernst, Fleming Gini F, Nakamura Yusuke
Abstract excerpt
Purpose: Current evolution of cancer immunotherapies, such as immune checkpoint blockade, has implicated neoantigens as major targets of anticancer cytotoxic T cells. Adoptive T-cell therapy with neoantigen-specific T-cell receptor (TCR)-engineered T cells would be an attractive therapeutic option for advanced cancers where the host antitumor immune function is strongly inhibited. We previously developed a rapid...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.