Article

NAT10 promotes the activation of hepatic stellate cells by modulating the TGF-β1-ac4C- COL1A1 axis

2025-08-25

Abstract excerpt

<title>Abstract</title> <p> Background Liver fibrosis is characterized by deposition of excessive extracellular matrix (ECM). The major source of ECM is activated hepatic stellate cells (HSCs). NAT10 is the only known acetyltransferase catalyzing ac4C RNA modification. The purpose of this study is to explore the role of NAT10 acting as ac4C acetyltransferase during HSC activation. Methods NAT10 was detected in f...

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Literature Corpus work: 6c0003de-4b96-578a-b989-d0b5c849b028
DOI: 10.21203/rs.3.rs-7284137/v1

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