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Article

NAT10 is upregulated in hepatocellular carcinoma and enhances mutant p53 activity.

BMC cancer - 31 Aug 2017

Li Qijiong, Liu Xiaofeng, Jin Kemin, Lu Min, Zhang Chunfeng, Du Xiaojuan, Xing Baocai

Abstract excerpt

BACKGROUND: N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which is involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is involved in the development of human cancers. Previous study showed that NAT10 acetylates the tumor suppressor p53 and regulates p53 activation. As Tp53 gene is frequently mutated in hepatocellular carcinoma (HCC) and associates with the...

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Share to Carcinoma, Hepatocellular
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Liver Neoplasms

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Share to Proto-Oncogene Proteins c-mdm2

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Source

Open in PubMed Open full text

Identifiers

PMID: 28859621
DOI: 10.1186/s12885-017-3570-4
PMCID: PMC5579925

Genes

NAT10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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