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Article

Aberrant outputs of glutamatergic neurons in deep cerebellar nuclei mediate dystonic movements

9 May 2025

Abstract excerpt

Dystonia, characterized by repetitive twisting movements or abnormal postures, has been linked to the deep cerebellar nuclei (DCN). However, the specific roles of distinct neuronal populations within the DCN in driving dystonic behaviors remain unclear. This study explores the contributions of three distinct groups of DCN neurons in an animal model of paroxysmal dystonia harboring a mutation in the proline-rich...

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PMID: 40344058
DOI: 10.1126/sciadv.adp2377

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