Article

Loss of Caspase-8 function in combination with SMAC mimetic treatment sensitizes Head and Neck Squamous Carcinoma to radiation through induction of necroptosis

2020-04-18

Abstract excerpt

Caspase-8 ( CASP8 ) is one of the most frequently mutated genes in head and neck squamous carcinomas (HNSCC), and mutations of CASP8 are associated with poor overall survival. The distribution of these mutations in HNSCC suggests that they are likely to be inactivating. Inhibition of CASP8 has been reported to sensitize cancer cells to necroptosis, a unique cell death mechanism. Here, we evaluated how CASP8 re...

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Literature Corpus work: 6b558c97-e05d-55aa-adf3-744bc002804a
DOI: 10.1101/2020.04.17.039040

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