Article

SNAI2-mediated direct repression of <i>BIM</i> protects rhabdomyosarcoma from ionizing radiation

2021-01-26

Abstract excerpt

Ionizing radiation (IR) and chemotherapy are the mainstays of treatment for patients with rhabdomyosarcoma (RMS). Yet, the molecular mechanisms that underlie the success or failure of radiotherapy remain unclear. The transcriptional repressor SNAI2 was previously identified as a key regulator of IR sensitivity in normal and malignant stem cells through its repression of the proapoptotic BH3-only gene PUMA. Here,...

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Literature Corpus work: a78568e1-a3e6-53be-a07a-ca1b65fbec6d
DOI: 10.1101/2021.01.25.428112

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