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Article

BRAF and AXL oncogenes drive RIPK3 expression loss in cancer

29 Aug 2018

Abstract excerpt

Necroptosis is a lytic programmed cell death mediated by the RIPK1-RIPK3-MLKL pathway. The loss of Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) expression and necroptotic potential have been previously reported in several cancer cell lines; however, the extent of this loss across cancer types, as well as its mutational drivers, were unknown. Here, we show that RIPK3 expression loss occurs...

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PMID: 30157175
DOI: 10.1371/journal.pbio.2005756

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