Article

Peripheral signature of altered synaptic integrity in young onset Cannabis Use Disorder: A proteomic study of circulating extracellular vesicles

2022-06-19

Abstract excerpt

<h4>Background</h4> The prevalence of cannabis use and Cannabis Use Disorder (CUD) are highest amongst adolescents and young adults. A lack of brain tissues from patients with CUD limits the ability to examine the molecular basis of cannabis related neuropathology. Proteomic studies of neuron-derived extracellular vesicles (NDEs) isolated from the biofluids may reveal markers of neuropathology in CUD. <h4>Methods<...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6b4cfaa1-8d4e-582a-a362-813aa4d6f296
DOI: 10.1101/2022.06.17.22276563

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peripheral signature of altered synaptic integrity in young onset Cannabis Use Disorder: A proteomic study of circulating extracellular vesiclesDOI 10.1101/2022.06.17.22276563Read

Cerebrospinal fluid biomarkers reveal transdiagnostic synaptic dysfunction across major psychiatric disordersSemantic proximity Read

Human post-mortem synapse proteome integrity screening for proteomic studies of postsynaptic complexesSemantic proximity Read

Analysis of Circulating Exosomes Reveals a Peripheral Signature of Astrocytic Pathology in SchizophreniaSemantic proximity Read

Extracellular Vesicle Phenotypic Trajectories During Alcohol Withdrawal Treatment.Semantic proximity Read

Proteomics in molecular medicine: applications in central nervous systems disorders.Semantic proximity Read

Characterization of RNA cargo from extracellular vesicles obtained from cerebrospinal fluid and plasma samples in schizophrenia participants and healthy volunteersSemantic proximity Read

Sex-based differences in the lipidomic profile of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxicationSemantic proximity Read

Lipidomic Landscape of Circulating Extracellular Vesicles Isolated from Adolescents Exposed to Ethanol Intoxication: A Sex Difference StudySemantic proximity Read

Reduced levels of synaptic vesicle protein 2A in the extracellular vesicles and brain of Alzheimer’s disease- associations with Aβ, tau and synaptophysinSemantic proximity Read

Proteome Analysis of Potential Synaptic Vesicle Cycle Biomarkers in the Cerebrospinal Fluid of Patients with Sporadic Creutzfeldt–Jakob DiseaseSemantic proximity Read

A Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue and Synaptosome Preparations from Frozen Post-Mortem Brain SamplesSemantic proximity Read

Molecular profiling of neuronal extracellular vesicles reveals brain tissue specific signalsSemantic proximity Read