Article

Alzheimer’s Disease, Piezo2 Channelopathy, Piezo1 Channelopathy and the Body-Wide Piezo2 System

2026-04-02

Abstract excerpt

A PIEZO2 variant was shown recently to protect against Alzheimer’s disease in the Hispanic population. This analysis implicates the potentially critical role of Piezo2 in Alzheimer’s disease pathophysiology. Another recent research mimicked acquired Piezo1 channelopathy by PIEZO1 manipulation. This study also showed that phosphatidylinositol 4,5-bisphosphate (PIP2) administration ameliorated brain capillary endoth...

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Literature Corpus work: 6b0be51f-bf21-5416-80fe-5d257432211a
DOI: 10.20944/preprints202604.0091.v1

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