Article

Sexually dimorphic role of estrogen receptor α in preserving right ventricular endothelial integrity

2025-11-21

Abstract excerpt

Right ventricular (RV) function and adaptation to afterload increase determine survival in pulmonary hypertension (PH). RV adaptation in PH is sexually dimorphic and more preserved in females, mediated by protective estrogen receptor α (ERα) signaling in cardiomyocytes. However, the effects of ERα on RV endothelial cells (RVECs), a critical mediator of RV homeostasis and adaptation, are unknown. We hypothesized th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6afea9c4-fcbe-5ea3-8f42-4d437e063734
DOI: 10.1101/2025.11.20.689545

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Sexually dimorphic role of estrogen receptor α in preserving right ventricular endothelial integrityDOI 10.1101/2025.11.20.689545Read

Estrogen receptor-α prevents right ventricular diastolic dysfunction and fibrosis in female rats.Semantic proximity Read

Unraveling the Role of Sex in Endothelial Cell Dysfunction: Evidence From Lineage Tracing Mice and Cultured CellsSemantic proximity Read

Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary HypertensionSemantic proximity Read

Transcriptomic Signature of Right Ventricular Failure in Experimental Pulmonary Arterial Hypertension: Deep Sequencing Demonstrates Mitochondrial, Fibrotic, Inflammatory and Angiogenic AbnormalitiesSemantic proximity Read

Microvascular preservation and cardiomyocyte hyperplasia underlie adaptive right ventricular development in congenital heart disease-associated pulmonary arterial hypertensionSemantic proximity Read

EGR1 Is Implicated in Right Ventricular Cardiac Remodeling Associated with Pulmonary HypertensionSemantic proximity Read

Transcriptomics and proteomics revealed sex differences in human pulmonary microvascular endothelial cellsSemantic proximity Read

Intrauterine Growth Restriction Programs Intergenerational Transmission of Pulmonary Arterial Hypertension and Endothelial Dysfunction via Sperm Epigenetic ModificationsSemantic proximity Read

Gender and cardiovascular disease: are sex-biased microRNA networks a driving force behind heart failure with preserved ejection fraction in women?Semantic proximity Read

Hypoxia‐induced pulmonary hypertension upregulates eNOS and TGF‐β contributing to sex‐linked differences in BMPR2+/R899X mutant miceSemantic proximity Read

Multicellular Programs Associated with Right Ventricular Adaptation in Pulmonary Arterial HypertensionSemantic proximity Read

Transcriptomic profiles reveal differences between the right and left ventricle in normoxia and hypoxiaSemantic proximity Read