Article

Umbilical cord-derived mesenchymal stromal cells attenuate neurogenic degeneration in infantile acute encephalopathy mice

2026-07-29

Abstract excerpt

<title>Abstract</title> <p>Objectives Infantile acute encephalopathy (AE) is characterized by impaired consciousness, fever, status epilepticus (SE), and a high frequency of cognitive dysfunction and mortality, without established treatment. We generated an infant AE mouse model and treated it with human umbilical cord-derived mesenchymal stromal cells (UC-MSCs). Methods The infant AE model mice demonstrated SE...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6ae3276e-f9d4-5bce-8601-d4a6fac86f35
DOI: 10.21203/rs.3.rs-10323825/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Umbilical cord-derived mesenchymal stromal cells attenuate neurogenic degeneration in infantile acute encephalopathy miceDOI 10.21203/rs.3.rs-10323825/v1Read

Human umbilical cord mesenchymal stem cells alleviate white-matter injury by regulating polarization of microgliaSemantic proximity Read

Human umbilical cord blood-derived mesenchymal stem cells improve neurological abnormalities of Niemann-Pick type C mouse by modulation of neuroinflammatory condition.Semantic proximity Read

Effects of human umbilical cord mesenchymal stem cell (hUC-MSC)-derived exosomes on HIBD immunoinflammation in neonatal ratsSemantic proximity Read

Role of astrocytes in the pathogenesis of perinatal brain injurySemantic proximity Read

Surfactant Protein A Attenuates Generalized and Localized Neuroinflammation In Neonatal MiceSemantic proximity Read

Targeted rescue of synaptic plasticity improves cognitive decline after severe systemic inflammationSemantic proximity Read

Effects of Sevoflurane on the Development of a Human Brain Microphysiological SystemSemantic proximity Read

A unique cerebellar pattern of microglia activation in a mouse model of encephalopathy of prematuritySemantic proximity Read

The mmu_circ_0000335 inhibits M1 microglial-induced hippocampal neuronal apoptosis via the miR-19b-3p/SOCS1 axis in a mouse epilepsy modelSemantic proximity Read

Bridging Stem Cell Models and Medicine: Integrated 3D Human Cerebral Organoids and Pediatric Serum Reveal Mechanisms and Biomarkers of Anesthetic-Induced NeurotoxicitySemantic proximity Read

Repeated Neonatal Sevoflurane Induced Neurocognitive Impairment Through NF-κB-Mediated PyroptosisSemantic proximity Read

Unconjugated bilirubin induces neuro-inflammation in an induced pluripotent stem cell-derived cortical organoid model of Crigler Najjar SyndromeSemantic proximity Read