Article

Mechanochemically-reprogrammed stem cell exosomes reconcile the biogenesis-internalization trade-off for pulmonary fibrosis therapy

2026-03-24

Abstract excerpt

Matrix stiffness serves as a pivotal biophysical cue that profoundly dictates exosome biogenesis and cellular internalization, yet often creates a functional trade-off that impedes clinical translation. Herein, we developed a mechano-chemo-transductive strategy to engineer mesenchymal stem cell (MSC) exosomes endowed with robust biogenesis and superior delivery potency. Specifically, we revealed that MSCs cultured...

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Identifiers and source

Literature Corpus work: 6ab56073-b1cd-5fda-bb5c-96fbafa99877
DOI: 10.64898/2026.03.20.713315

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