Article

Intracorneal delivery of HSV-targeting CRISPR/Cas9 mRNA prevents herpetic stromal keratitis

2020-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Herpes simplex virus type 1 (HSV-1) is a leading cause of infectious blindness. Current treatments for HSV-1 do not eliminate the virus and are incapable of modulating the virus reservoir. Here, we target HSV-1 genome directly using mRNA-carrying lentiviral particle (mLP) that simultaneously delivers spCas9 mRNA and two viral genes-targeting gRNAs (designated HSV-1-erasing lentiviral particles,...

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Literature Corpus work: 6a903d07-579f-5912-a52a-346d403431a1
DOI: 10.1101/2020.02.08.934125

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