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Potential Application of the CRISPR/Cas9 System against Herpesvirus Infections

29 May 2018

Abstract excerpt

The CRISPR/Cas9 system has been applied in the genome editing and disruption of latent infections for herpesviruses such as the herpes simplex virus, Epstein⁻Barr virus, cytomegalovirus, and Kaposi's sarcoma-associated herpesvirus. CRISPR/Cas9-directed mutagenesis can introduce similar types of mutations to the viral genome as can bacterial artificial chromosome recombination engineering, which maintains and...

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PMID: 29844277
DOI: 10.3390/v10060291

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