Article

In Vivo CRISPR Gene Editing in Patients with Herpes Stromal Keratitis

2023-02-24

Abstract excerpt

In vivo CRISPR gene therapy holds large clinical potential, but the safety and efficacy remain largely unknown. Here, we injected a single dose of HSV-1-targeting CRISPR formulation in the cornea of three patients with severe refractory herpes stromal keratitis (HSK) during corneal transplantation. Our study is an investigated initiated, open-label, single-arm, non-randomized interventional trial at a single cente...

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Literature Corpus work: 0592ed38-2988-59b2-8350-ada07d90198f
DOI: 10.1101/2023.02.21.23285822

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