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Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants

9 Nov 2022

Abstract excerpt

Herpes simplex virus (HSV) infection is a leading cause of corneal blindness. However, keratoplasty is only rarely proposed due to the high frequency of graft failure and associated recurrences. Gene therapy of the corneal graft might provide sustained protection against HSV infection. To test that hypothesis, we designed a meganuclease specific to an HSV-1 DNA sequence coding for major capsid protein (UL19) and...

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PMID: 36457698
DOI: 10.1016/j.omtn.2022.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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